Description
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney (PubMed: 20921420). Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts (PubMed: 20921420). Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity